I have windows 10 and i have never experienced lag or freezes ingame since the start of the open beta
but few days ago my windows 10 got a "security update", and since then i got random freezes every 30 seconds or so.
the code of the update was KB4343909
forum.dboglobal.to/wsc/index.php?attachment/2732/
yesterday i uninstalled it and my game got back to normal, (and didn't even needed to disable Windows Defender)
so if you have random freezes ingame, check your windows update history, look for that specific update and uninstall it